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Effect Of Acute In Vivo Sildenafil Citrate And In Vitro
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Table 4 Total and free plasma concentrations, semen concentrations and total amount of drug in semen for sildenafil and UK, Sperm and ejaculate properties were evaluated from semen samples taken at screening and 1. The concentrations of UK, in the semen at 1. Stimulation of ejaculated human spermatozoa by caffeine. This is important, because sperm motility how effectively they move , and sperm morphology how normally they are shaped are important factors in what makes sperm successful. Effect of sildenafil on sperm motility parameters. For both semen and plasma, assays for the drug and its metabolite were conducted using automated sequential trace enrichment of dialysates and previously validated high-pressure liquid chromatography with ultraviolet detection [ 18 ]. The sponsor of the study provided sildenafil as mg tablets and matching placebo tablets, and the order of dosing was randomized. Distribution of the N -desmethyl metabolite UK, into the semen appeared to lag behind that of the parent drug, even though the times to achieve maximum observed plasma concentration values were concurrent. Assessments Sperm and semen parameters Semen samples were obtained at screening and 1. Statistical evaluation Sperm motility parameters were subject to analysis of variance that ascribed variation in the data to subjects, periods, treatments, subject-by-period interaction and analysis time. The most frequently reported adverse events were flushing, headache, dizziness and abnormal vision and were generally mild to moderate in severity. The results of this study clearly indicate that single oral doses of sildenafil mg can be safely administered without concern on the part of the physician or the patient regarding adverse effects on sperm or ejaculate quality.
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